Unbeknownst to me in years before I discovered this: my diabetic husband’s endocrinologist had him on Crestor and I found out randomly because he shares nothing- that she had his TOTAL CHOLESTEROL at or below 100 for at least 7 years!! I discovered this in 2015- shortly after AHA “expanded” guidelines to put MORE people on statins. No one would have considered this a problem at the time. Reached out 2021 to Dr claiming to be integrative- did nothing. I can tell you without a doubt he has a brain injury from it. But a) no one cares and b) he is in denial and won’t do anything about it. In meantime he functions as you would suspect someone with a brain injury does (think football and post concussive syndrome) . I am disgusted
The article below backs up the points raised above: Brain cholesterol homeostasis and its association with neurodegenerative diseases. Dr Georgia Ede (Primal Podcast interview) also points out that most statins pass through the blood brain barrier, thereby suppressing de novo cholesterol synthesis by the brain. I would add that the demonisation of eggs (cholesterol, choline, Omega 3, lutein) has also contributed to mental decline. https://www.sciencedirect.com/science/article/abs/pii/S0197018623001638
Extracts from this article:
It is widely acknowledged that cholesterol within the brain predominantly originates from de novo synthesis, a process exclusively maintained due to the impermeability of the BBB to cholesterol-laden lipoproteins (Zhang and Liu, 2015). In the CNS, cholesterol is synthesized primarily by neurons, astrocytes and oligodendrocytes (Fig. 1). Accumulation of brain cholesterol is closely related to myelin formation.
Beyond its crucial contributions to cell membrane composition and the synthesis of bile acids and steroid hormones, cholesterol plays an indispensable role in ensuring the survival and development of neurons, facilitating signal transduction, and contributing to myelin formation and synaptogenesis within CNS (Pfrieger, 2003a; Valenza and Cattaneo, 2006). However, the presence of BBB necessitates the CNS to primarily rely on de novo cholesterol synthesis, rather than the uptake of plasma lipoproteins from circulation (Zhang and Liu, 2015)....
Approximately 70% of the cholesterol in the adult brain finds its predominant residence within myelin membranes, where it assumes a pivotal role in insulating axons, under the guidance of oligodendrocytes.
I love Dr Joe but his online products are too expensive. But Doc, you are right on about cholesterol. The carnivore community agrees. The people living the longest with a good brain have higher cholesterol levels than the people who listen to western medicine pushers and the statin industry. Your triglyceride level divided by your HDL tells you when to be worried.
In his book Murder by Injection Eustace Mullins shows Alzheimers linked to flouride, which is a by product of aluminum industry. A generation was also raised eating from aluminum cookware. There does seem to be an interesting timeline here with the new disease.
ALCOA bought off Congress to dispose of flouride in the water system.
I could tell within months of my husband on a statin, then Repatha, he would be dysfunctional intellectually, if not physically, if he continued. The man is brilliant and his thinking dulled within weeks. Add to the statins, the “lol” beta blockers, repurposed anti anxiety meds, like metoprolol, which also cross the blood brain barrier and increase insulin resistance, and it’s all witches brew, imo.
His cardiologist switched him to Carvedilol after I brought him the studies about metoprolol elevating blood sugar in some patients. He’s halved his dose now, and his blood pressure has not gone up while at rest. In fact, he says he feels better at a higher blood pressure.
Thirty years ago my Doc tried several different lols for my arrhythmia w PVC’s, lastly Atenolol with slightly less brain effect. Needless to say, I’ve lived 30 years comfortably without beta blockers until recently, and trying dietary changes and breath training.
My Harvard trained cardiologist did not believe me until I brought him the studies showing a small percentage of the population has deleterious effects from these medications. I like my brain working, thank you.
I’m a new subscriber, so my apologies if Dr Sircus has addressed this earlier, but if not, I’d love to know your thoughts since many seniors are on statins and likely prescribed a beta blocker along with aspirin and other blood thinners.
Are the pathways for brain myelin the same for neuropathy sufferers? Or Is blood sugar the devil in neuropathy?? Why is that issue so failed, so many people suffer with it.
Perfectly stated. More people need to question their doctor’s automatic jump to prescribe statins when cholesterol inevitably rises when we age.
I will also point out that our hormones are synthesized with cholesterol. So that when our hormones drop as we age (especially for women), it seems obvious that our cholesterol levels would rise?
Cholesterol is essential for brain structure and function, but the relationship between blood cholesterol, medications like statins, and long-term neurological outcomes is complex and still actively studied in modern medicine.
Unbeknownst to me in years before I discovered this: my diabetic husband’s endocrinologist had him on Crestor and I found out randomly because he shares nothing- that she had his TOTAL CHOLESTEROL at or below 100 for at least 7 years!! I discovered this in 2015- shortly after AHA “expanded” guidelines to put MORE people on statins. No one would have considered this a problem at the time. Reached out 2021 to Dr claiming to be integrative- did nothing. I can tell you without a doubt he has a brain injury from it. But a) no one cares and b) he is in denial and won’t do anything about it. In meantime he functions as you would suspect someone with a brain injury does (think football and post concussive syndrome) . I am disgusted
The article below backs up the points raised above: Brain cholesterol homeostasis and its association with neurodegenerative diseases. Dr Georgia Ede (Primal Podcast interview) also points out that most statins pass through the blood brain barrier, thereby suppressing de novo cholesterol synthesis by the brain. I would add that the demonisation of eggs (cholesterol, choline, Omega 3, lutein) has also contributed to mental decline. https://www.sciencedirect.com/science/article/abs/pii/S0197018623001638
Extracts from this article:
It is widely acknowledged that cholesterol within the brain predominantly originates from de novo synthesis, a process exclusively maintained due to the impermeability of the BBB to cholesterol-laden lipoproteins (Zhang and Liu, 2015). In the CNS, cholesterol is synthesized primarily by neurons, astrocytes and oligodendrocytes (Fig. 1). Accumulation of brain cholesterol is closely related to myelin formation.
Beyond its crucial contributions to cell membrane composition and the synthesis of bile acids and steroid hormones, cholesterol plays an indispensable role in ensuring the survival and development of neurons, facilitating signal transduction, and contributing to myelin formation and synaptogenesis within CNS (Pfrieger, 2003a; Valenza and Cattaneo, 2006). However, the presence of BBB necessitates the CNS to primarily rely on de novo cholesterol synthesis, rather than the uptake of plasma lipoproteins from circulation (Zhang and Liu, 2015)....
Approximately 70% of the cholesterol in the adult brain finds its predominant residence within myelin membranes, where it assumes a pivotal role in insulating axons, under the guidance of oligodendrocytes.
I love Dr Joe but his online products are too expensive. But Doc, you are right on about cholesterol. The carnivore community agrees. The people living the longest with a good brain have higher cholesterol levels than the people who listen to western medicine pushers and the statin industry. Your triglyceride level divided by your HDL tells you when to be worried.
Interesting theory.
In his book Murder by Injection Eustace Mullins shows Alzheimers linked to flouride, which is a by product of aluminum industry. A generation was also raised eating from aluminum cookware. There does seem to be an interesting timeline here with the new disease.
ALCOA bought off Congress to dispose of flouride in the water system.
I could tell within months of my husband on a statin, then Repatha, he would be dysfunctional intellectually, if not physically, if he continued. The man is brilliant and his thinking dulled within weeks. Add to the statins, the “lol” beta blockers, repurposed anti anxiety meds, like metoprolol, which also cross the blood brain barrier and increase insulin resistance, and it’s all witches brew, imo.
His cardiologist switched him to Carvedilol after I brought him the studies about metoprolol elevating blood sugar in some patients. He’s halved his dose now, and his blood pressure has not gone up while at rest. In fact, he says he feels better at a higher blood pressure.
Thirty years ago my Doc tried several different lols for my arrhythmia w PVC’s, lastly Atenolol with slightly less brain effect. Needless to say, I’ve lived 30 years comfortably without beta blockers until recently, and trying dietary changes and breath training.
My Harvard trained cardiologist did not believe me until I brought him the studies showing a small percentage of the population has deleterious effects from these medications. I like my brain working, thank you.
I’m a new subscriber, so my apologies if Dr Sircus has addressed this earlier, but if not, I’d love to know your thoughts since many seniors are on statins and likely prescribed a beta blocker along with aspirin and other blood thinners.
https://drsircus.com/cardiovascular/statins-cholesterol-and-the-brain-did-medicine-declare-war-on-a-molecule-of-life/
https://drsircus.com/cardiovascular/statins-cholesterol-and-the-brain-did-medicine-declare-war-on-a-molecule-of-life/
Are the pathways for brain myelin the same for neuropathy sufferers? Or Is blood sugar the devil in neuropathy?? Why is that issue so failed, so many people suffer with it.
Perfectly stated. More people need to question their doctor’s automatic jump to prescribe statins when cholesterol inevitably rises when we age.
I will also point out that our hormones are synthesized with cholesterol. So that when our hormones drop as we age (especially for women), it seems obvious that our cholesterol levels would rise?
Cholesterol is essential for brain structure and function, but the relationship between blood cholesterol, medications like statins, and long-term neurological outcomes is complex and still actively studied in modern medicine.